Antibiotics and immunodeficiency

Antibiotics and immunodeficiency2023-10-09T11:17:53+00:00

Antibiotics and immunodeficiency

Antibiotics are important medicines for managing and treating infections caused by bacteria. This information for people with a primary immunodeficiency (PID) or a secondary immunodeficiency (SID) and their carers aims to promote the safe and effective use of antibiotics and aims to answer some of the frequently asked questions we have received.

You can download our booklet on this topic here.

What are antibiotics?

Antibiotics are medicines used to treat infections caused by bacteria – one type of ‘bugs’ that cause illness. They work either by killing the bacteria or by slowing their growth. Antibiotics are used to treat immunodeficiencies to:

  • To treat bacterial infections such as chest, sinus or ear infections
  • As prophylaxis – prolonged treatment with the aim of preventing bacterial infection or reducing its frequency, or severity.

What types of antibiotics are available?

There are many different types of antibiotics that are used to treat different kinds of bacterial infections. Antibiotics are often categorised by their ‘spectrum’ of activity.

A ‘broad-spectrum’ antibiotic is one that acts against a wide variety of bacteria. Examples of broad-spectrum antibiotic tablets often used in immunodeficiency include co-amoxiclav, doxycycline or azithromycin.

Other antibiotics work against certain types of bacteria and are only used in very specific circumstances, such as when laboratory test results identify specific bacteria.

Which antibiotic should you take?

Your doctor will decide which antibiotic is appropriate for you based on your clinical history, examination and laboratory results (e.g. which bacteria grow from a sputum sample). In addition, each hospital will have local guidance on antibiotic use to support your doctor in the decision-making process.

Please remember to always give a sputum sample, where possible, before taking antibiotics for a chest infection. This might help your doctor make decisions on antibiotic treatment now and in the future.

How to take antibiotics

Antibiotic treatment is usually given by mouth in tablet form (or suspensions for children). Antibiotics can also be administered into a vein (intravenous) or for certain infections, they are applied directly to the affected part of the body (topical; e.g. antibiotic eye drops). Occasionally and for very specific lung infections inhaled (nebulised) antibiotics may be used.

The do’s and don’ts

If your doctor has decided that antibiotics are necessary, it is very important to take them in a responsible manner.

  • Follow the instructions on the label or patient information sheet. Some antibiotic tablets are best taken on an empty stomach (an hour before or two hours after meals), whilst others should not be taken with certain foods.
  • Take the antibiotics at the correct time and complete the course. Not completing the course might contribute to bacteria becoming ‘antibiotic resistant’ and the antibiotic being less effective in the future. This is particularly important in immunodeficiency as antibiotics can sometimes be required regularly.
  • Tell your doctor if your symptoms continue to get worse, you are unable to take the prescribed antibiotics, or you experience unacceptable side effects.

However, certain antibiotics do not work very well (or at all) when given orally for severe infections. Your doctor may then decide that intravenous antibiotics are needed. Intravenous antibiotics are often used for the most severe infections. In these situations, intravenous antibiotics are necessary. In these situations, hospital admission (for giving intravenous antibiotics) is often required but longer-term administration can sometimes be facilitated at home.

Remember

You should always complete the antibiotic course, even if you start to feel better.

What are the possible complications of taking antibiotics?

Antibiotics are safe and highly effective medications, but as with all therapies, there are sometimes unwanted effects (side-effects or adverse events):

  • Nausea, vomiting and diarrhoea are the most common side effects. Experiencing one or more of these side effects may mean that the particular antibiotic your doctor has prescribed is not suitable for you at this time. You should contact the prescribing team for further advice on what to do next.
  • Occasionally antibiotics lead to a fungal infection, or ‘thrush’ of the mouth, digestive tract or vagina. This is rarely serious and is readily treated with antifungal drops and creams where necessary.
  • Allergy to antibiotics is rare. Antibiotics can lead to rashes, swelling of the skin or tongue and difficulty breathing. If you have had a reaction to an antibiotic in the past, it is important to remind your doctor, nurse or pharmacist of this because your reaction may have an impact on the types of antibiotics you are given in the future.

Important

If you get a reaction while on the antibiotic inform your doctor immediately. If you are unable to contact your doctor, stop the antibiotic and continue to try and get through to your medical team.

You can also report a side-effects or adverse event through the Yellow Card Scheme.

Interactions with other medications

Some antibiotics can affect how other medications work. For example, some make the oral contraceptive pill less effective, in which case you may need to use a different or additional form of contraception. Some may affect the activity of blood thinning medication, such as warfarin, or tablets used to control epilepsy. Your doctor, nurse or pharmacist will be happy to help you with any concerns.

How is the use of antibiotics in immunodeficiency different?

The use of antibiotics in immunodeficiency may differ from general use in a number of ways.

Occasionally it may be necessary to remind a healthcare professionals of these differences. This may be particularly important when dealing with locum staff (staff that fill temporary positions in healthcare settings), as they may not have full medical details to hand.

The main differences are:

  • Longer courses and stronger courses

Patients with immunodeficiency are often prescribed longer and stronger courses of antibiotics than usual. This might mean courses of 14 days, or sometimes longer. The reason for this is to prevent relapse or recurrence of infection. As always, you must complete the course even if you are feeling better.

  • Stand-by antibiotics at home

Under certain circumstances a ‘reserve’ course of antibiotics to be kept at home may be recommended. Your doctor will give you very specific advice regarding when these antibiotics are to be used. It can be helpful to collect a sputum sample (in the case of a chest infection) before these emergency antibiotics are started. This can be dropped into your family practice. You should keep a record of when you use these stand-by antibiotics, and obtain a replacement supply after they have been used.

  • Long-term (prophylactic) antibiotics (see section below)

Antibiotics are often prescribed for much longer periods of time with the aim of reducing the number and severity of infections. As with all antibiotics, it is particularly important to take them exactly as prescribed and not to skip or miss doses.

Four golden rules of taking antibiotics

  1. Always take your antibiotics as exactly as directed.
  2. Always complete the course.
  3. Inform your doctor, nurse or pharmacist if you experience side effects.
  4. Seek advice from your medical team if you do not feel better or you think things are getting worse.

About prophylactic antibiotics

Long-term antibiotics are often used in immunodeficiency to reduce the number and severity of infections. They can be used as a standalone treatment or added to other therapies, such as immunoglobulin replacement. While much of what we know about antibiotic prophylaxis is taken from studies in conditions such as cystic fibrosis and bronchiectasis, this treatment approach has been found to be very effective by doctors specialising in immunodeficiency and is common practice.

The choice and dose of prophylactic antibiotic depends on the type of immunodeficiency; the presence of complications such as lung, sinus or ear disease; information from previous laboratory tests; and local guidelines on antibiotic use. Patient-specific concerns, such as dosing intervals and previous side effects, are also taken into account when making a selection.

Your doctor will carefully weigh up the risks and benefits of using antibiotic prophylaxis before offering this treatment. How well this treatment strategy works will be an important part of your regular follow-up. If you and your doctor find no noticeable benefit from long-term antibiotics, then they may prescribe an alternative or discontinue them entirely. Prophylactic antibiotics will never be prescribed without good reason.

Prophylactic antibiotics are well tolerated and problems with their use are not common. Concerns have been raised about the impact of certain antibiotic families on the heart, liver or kidneys, when used for long periods. This may be particularly relevant for older patients and those with known pre-existing problems. If your doctor is considering the use of such medications, he or she may wish to undertake additional tests and discuss the risks with you before starting this approach.

Antibiotic resistance

Antibiotic resistance means that antibiotics do not work as well to treat certain infections as they used to.. Antibiotic resistance is a concern for all doctors and patients alike. Studies in other diseases do suggest that long-term use of certain antibiotic drugs can contribute to a level of resistance, but this has not been well studied in immunodeficiency. Some specialists will change a patient’s antibiotics every few months in an attempt to avoid resistance, but the benefit of this approach is uncertain.

At present, the best advice to minimise resistance, is to take the antibiotic regime exactly as prescribed by your team never skip doses and complete the course of treatment even if you feel better. Make sure you also raise any concerns you have with your specialist directly.

Frequently asked questions about antibiotics

I have a PID and I take antibiotics on a regular basis and I’m worried about developing antibiotic resistance. What advice can you give?2021-04-01T15:58:26+00:00

Individuals colonized with or exposed to certain bacteria may develop antimicrobial resistance. This will  require a change in therapy so that the particular bacteria is eradicated. Where eradication is not possible, there may still be better suppression with an alternative agent and the resistant strain may die out allowing the original agent to be effective again. Antibiotic prophylaxis is only advocated when all the benefits outweigh all the risks and resistance is one of those.

Is it helpful to take probiotics when you are taking antibiotics?2021-04-01T15:57:51+00:00

People who are on antibiotics may benefit from taking probiotics at the same time, a review of evidence has shown. Read more at http://www.bbc.com/future/story/20190124-is-it-worth-taking-probiotics-after-antibiotics This may help people with primary antibody deficiency but make sure your probiotic products are from a reputable company with quality assurance as to the strains contained within them.

What are the pros and cons of taking prophylactic antibiotics versus taking ad hoc antibiotics i.e. when they are needed?2023-04-18T15:48:16+00:00

Your doctor will decide what is most appropriate on the medical history and frequency of infections. Treating each infection as they come, if they are frequent, by antibiotics allows inflammation in the tissues and may cause damage e.g. bronchiectasis or chronic sinus disease.  A few infections will always occur, but if this is less than 3-4 times per year, long term health complications are unlikely.  Preventative antibiotics will help break the cycle of recurrent infection and tissue damage.  In some people they will also slow down the rate of invasive infection, the function your immune system normally undertakes.  That gives time to get to a doctor or hospital for serious infection and then receive the appropriate treatment, without a more serious e.g. sepsis occurring. Take a look at our antibiotic information here.

My daughter has been on antibiotics for the last year but is still having recurrent infections. Her Paediatrician is referring her to an Immunologist and has suggested either different antibiotics or immunoglobulin infusions. Which treatment course would be best for her?2021-04-01T15:56:32+00:00

Your daughter’s Paediatrician is right to refer her to an Immunologist. They will conduct more tests and look at her levels, they will then decide which treatment option is best.

I started infusions about 6 months ago and have had my first infection over the weekend. Should I take the emergency antibiotics I have at home and then ring my immunology centre on Monday, or wait until Monday and get a doctors appointment?2021-04-01T13:30:31+00:00

Your clinic should give you advice about how to manage intercurrent infection.  If you are not sure that you are unwell enough to need to take antibiotics, they may not be needed and you could wait until Monday.  If it is a definite bacterial infection, then you should start antibiotics, following the guidance given to you by the prescriber and then let the clinic know as soon as you can (e.g. after the weekend).  Lots of clinics would like you to provide a sputum sample for analysis just before you start antibiotics if possible and may have provided you with sputum pots for that purpose.

This page was reviewed by the Medical Advisory Panel, January 2018. Updated November 2021.

I have a PID and I take antibiotics on a regular basis and I’m worried about developing antibiotic resistance. What advice can you give?2021-04-01T15:58:26+00:00

Individuals colonized with or exposed to certain bacteria may develop antimicrobial resistance. This will  require a change in therapy so that the particular bacteria is eradicated. Where eradication is not possible, there may still be better suppression with an alternative agent and the resistant strain may die out allowing the original agent to be effective again. Antibiotic prophylaxis is only advocated when all the benefits outweigh all the risks and resistance is one of those.

Is it helpful to take probiotics when you are taking antibiotics?2021-04-01T15:57:51+00:00

People who are on antibiotics may benefit from taking probiotics at the same time, a review of evidence has shown. Read more at http://www.bbc.com/future/story/20190124-is-it-worth-taking-probiotics-after-antibiotics This may help people with primary antibody deficiency but make sure your probiotic products are from a reputable company with quality assurance as to the strains contained within them.

What are the pros and cons of taking prophylactic antibiotics versus taking ad hoc antibiotics i.e. when they are needed?2023-04-18T15:48:16+00:00

Your doctor will decide what is most appropriate on the medical history and frequency of infections. Treating each infection as they come, if they are frequent, by antibiotics allows inflammation in the tissues and may cause damage e.g. bronchiectasis or chronic sinus disease.  A few infections will always occur, but if this is less than 3-4 times per year, long term health complications are unlikely.  Preventative antibiotics will help break the cycle of recurrent infection and tissue damage.  In some people they will also slow down the rate of invasive infection, the function your immune system normally undertakes.  That gives time to get to a doctor or hospital for serious infection and then receive the appropriate treatment, without a more serious e.g. sepsis occurring. Take a look at our antibiotic information here.

My daughter has been on antibiotics for the last year but is still having recurrent infections. Her Paediatrician is referring her to an Immunologist and has suggested either different antibiotics or immunoglobulin infusions. Which treatment course would be best for her?2021-04-01T15:56:32+00:00

Your daughter’s Paediatrician is right to refer her to an Immunologist. They will conduct more tests and look at her levels, they will then decide which treatment option is best.

I started infusions about 6 months ago and have had my first infection over the weekend. Should I take the emergency antibiotics I have at home and then ring my immunology centre on Monday, or wait until Monday and get a doctors appointment?2021-04-01T13:30:31+00:00

Your clinic should give you advice about how to manage intercurrent infection.  If you are not sure that you are unwell enough to need to take antibiotics, they may not be needed and you could wait until Monday.  If it is a definite bacterial infection, then you should start antibiotics, following the guidance given to you by the prescriber and then let the clinic know as soon as you can (e.g. after the weekend).  Lots of clinics would like you to provide a sputum sample for analysis just before you start antibiotics if possible and may have provided you with sputum pots for that purpose.

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