Sometimes a BMT doesn’t “take” because the graft is rejected. In that situation, it may be possible to consider doing another transplant. However, this is dependent on whether the original donor is suitable or whether another suitable donor can be found. The medical condition of the patient considered for subsequent transplant has to be good enough for it to be attempted. There can also be a build-up of toxicity in the body from the chemicals used to prepare the body for transplant during chemotherapy which can complicate further attempts at BMT. Second transplants have been done successfully for a number of PID patients but as mentioned above, a number of different factors need to be taken into account.