Once doctors have exhausted the possibility of finding a related donor within the family then they will begin the search of a match on national registries such as the Anthony Nolan Registry and cord stem cell banks.  Searches can also be made worldwide through international registries.  Umbilical cord blood may be used, and haploidentical transplants are on the increase as above if no suitable matched donor is available.  Finally, for some patients with no matched donor, gene therapy is an option and the number of indications where this is possible has increased over the last few years.