Treatment of CID

In the UK there are several specialist paediatric immunology centres that can
diagnose and often treat CID. Care is usually shared between the specialist
centre and paediatricians in the local centre and other specialties, such as
gastroenterologists or lung specialists, as well as the child’s family doctor (GP).

Initial management

The immediate priorities are to treat any current infection, to prevent new infections and to perform appropriate tests and assessments. Other complications, such as autoimmunity, may require specific treatment. Depending on the severity and type of condition, it may be appropriate to think about treatments designed to fix the faulty immune system permanently.

Simple measures to prevent infection in more severely affected children include drinking cooled, boiled water instead of water straight from the tap. If a child with CID is exposed to chickenpox or shingles, especially for the first time, they may need an urgent injection and/or medicine to protect them, so contact your healthcare team straight away.


In many cases, vaccines will already have been given before the diagnosis of CID
is made. Most of these are completely safe and do not cause problems. Some
live vaccines might need to be avoided, particularly BCG, rotavirus, measles/
mumps/rubella (MMR) and chickenpox (VZV, not in the routine immunisation
schedule in the UK, but routinely given in other countries).

Immunoglobulin (antibody) therapy

Children affected by CID often have problems producing antibodies, leaving
them vulnerable to infection. This can be corrected by immunoglobulin
, made from a solution of human antibodies. Further information about
immunoglobulin treatment can be found in a range of our leaflets.

Reviewed November 2017