Bone marrow transplantation (BMT)

What happens if a BMT match cannot be found within the family?

Once doctors have exhausted the possibility of finding a related donor within the family then they will begin the search of a match on national registries such as the Anthony Nolan Registry and cord stem cell banks.  Searches can also be made worldwide through international registries.  Umbilical cord blood may be used, and haploidentical transplants

What happens if a BMT match cannot be found within the family?2023-04-18T14:36:49+00:00

Can parents be a bone marrow match and so a donor for their child?

BMT works best when there is a 100% or 90% match of important markers on cells between the donor and the person having the BMT.  A brother or sister has a 25% chance of being a perfect match and are often used as donors.  A parent is usually only a 50% match so traditionally not always

Can parents be a bone marrow match and so a donor for their child?2023-04-18T14:36:21+00:00

Why is BMT for adults more difficult than that for a child?

Usually adults who are being considered for BMT have had chronic problems such as lung and gut disease over a long period of time. The accumulation of tissue damage from these chronic problems and infections often make BMT more difficult. Also because of the risks of BMT, the choices of whether a BMT is the

Why is BMT for adults more difficult than that for a child?2023-04-18T14:35:16+00:00

Is BMT only possible for children with PID?

No over the past few years, more adults have started to be treated by BMT but the numbers are still low.  One recent major advance has been the development of what is known as ‘reduced-intensity conditioning’; this is a milder form of chemotherapy used to prepare the patient for the donor’s bone marrow. This has

Is BMT only possible for children with PID?2023-04-18T14:34:50+00:00

Is a bone marrow transplant an option for people with CVID?

This depends on the type of CVID, its genetic basis and the health problems, past and present that the person may have.  CVID is probably a collection of multiple genetic disorders with sufficient common features for them to be given the same umbrella diagnostic label.  From our current understanding, some immune deficiency is caused by

Is a bone marrow transplant an option for people with CVID?2023-04-18T14:34:08+00:00

Do all SCID children need to have conditioning before they have a BMT?

This all depends on the type of SCID and how tissue type compatible the donor cells are. For some children with SCID with a perfect tissue match from their brother or sister conditioning using chemotherapy may not be necessary at all if the transplant is undertaken early enough in life. 

Do all SCID children need to have conditioning before they have a BMT?2023-04-18T14:33:29+00:00

How often can you do a bone marrow transplant (BMT) for a PID?

Sometimes a BMT doesn’t “take” because the graft is rejected.  In that situation, it may be possible to consider doing another transplant. However, this is dependent on whether the original donor is suitable or whether another suitable donor can be found.  The medical condition of the patient considered for subsequent transplant has to be good

How often can you do a bone marrow transplant (BMT) for a PID?2023-04-18T14:32:57+00:00

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